Human Drug Metabolism: An Introduction

Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body.  It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine.

This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understanding  of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems.

Content:
Chapter 1 Introduction (pages 1–12):
Chapter 2 Drug Biotransformational Systems – Origins and Aims (pages 13–22):
Chapter 3 How Phase I Systems Metabolize Substrates (pages 23–56):
Chapter 4 Induction of Phase I Systems (pages 57–73):
Chapter 5 Phase I Enzyme Inhibition (pages 75–99):
Chapter 6 Phase II and III Processes (pages 101–130):
Chapter 7 Factors Affecting Drug Metabolism (pages 131–162):
Chapter 8 Role of Metabolism in Drug Toxicity (pages 163–214):